{"id":196,"date":"2021-06-15T12:18:29","date_gmt":"2021-06-15T04:18:29","guid":{"rendered":"http:\/\/buzzorange.com\/citiorange\/2021\/06\/15\/taiwan-covid-19-vaccine\/"},"modified":"2021-09-01T18:05:10","modified_gmt":"2021-09-01T10:05:10","slug":"taiwan-covid-19-vaccine","status":"publish","type":"post","link":"https:\/\/buzzorange.com\/citiorange\/2021\/06\/15\/taiwan-covid-19-vaccine\/","title":{"rendered":"\u3010\u570b\u7522\u75ab\u82d7\u80fd\u6253\u55ce\uff1f\u5b78\u8005\u5728\u610f\u6307\u6a19\u5927\u4e0d\u540c\u3011\u514d\u75ab\u6a4b\u63a5\u8a66\u9a57\u3001\u4e2d\u548c\u6297\u9ad4\u6578\u64da\u5404\u6709\u8ad6\u8ff0\u91cd\u9ede"},"content":{"rendered":"<p>\uff08\u672c\u6587\u7d93\u5408\u4f5c\u5925\u4f34 \u601d\u60f3\u5766\u514b \u6388\u6b0a\u8f49\u8f09\uff0c\u4e26\u540c\u610f BuzzOrange \u7de8\u5beb\u5c0e\u8b80\u8207\u4fee\u8a02\u6a19\u984c\uff0c\u539f\u6587\u6a19\u984c\u70ba <a href=\"https:\/\/voicettank.org\/%E5%9C%8B%E7%94%A2%E7%96%AB%E8%8B%97%E7%B7%8A%E6%80%A5%E4%BD%BF%E7%94%A8%E6%8E%88%E6%AC%8A%E7%88%AD%E8%AD%B0%E8%88%87%E5%9B%A0%E6%87%89%E8%B7%AF%E5%BE%91%E4%B8%8A\/\">\u3008\u570b\u7522\u75ab\u82d7\u7dca\u6025\u4f7f\u7528\u6388\u6b0a\u722d\u8b70\u8207\u56e0\u61c9\u8def\u5f91\uff08\u4e0a\uff09\u3009<\/a>\u3002\u9996\u5716\u4f86\u6e90\uff1a<a href=\"https:\/\/pixabay.com\/zh\/users\/fernandozhiminaicela-6246704\/\">fernandozhiminaicela<\/a>)<\/p>\n<blockquote><p>\u3010\u70ba\u4ec0\u9ebc\u6211\u5011\u6311\u9078\u9019\u7bc7\u6587\u7ae0\u3011<\/p>\n<p>\u570b\u7522\u75ab\u82d7\u7684\u7814\u88fd\u727d\u6d89\u79d1\u5b78\u5c08\u696d\u3001\u570b\u6c11\u5065\u5eb7\u3001\u5168\u7403\u4eba\u9053\u95dc\u61f7\u3001\u570b\u5bb6\u5b89\u5168\u8207\u5730\u7de3\u653f\u6cbb\u7b49\u591a\u500b\u9762\u5411\uff0c\u5728\u63a2\u8a0e\u75ab\u82d7\u65bd\u6253\u8b70\u984c\u6642\uff0c\u91ab\u5b78\u79d1\u5b78\u8207\u91ab\u5b78\u502b\u7406\u554f\u984c\uff0c\u9700\u8981\u8a8d\u771f\u770b\u5f85\uff0c\u9700\u8981\u901a\u76e4\u601d\u7d22\u3002<\/p>\n<p>\u5728\u91ab\u754c\u548c\u516c\u885b\u754c\uff0c\u5c0d\u65bc\u570b\u7522\u75ab\u82d7\u4e8c\u671f\u5982\u679c\u89e3\u76f2\u6210\u529f\uff0c\u80fd\u5426\u7d66\u4e88\u7dca\u6025\u4f7f\u7528\u6388\u6b0a\uff08EUA\uff09\uff0c\u5206\u6210\u5169\u6d3e&#8212;-\u6642\u6548\u6d3e\u8207\u6a19\u898f\u6d3e\uff0c\u672c\u6587\u5e36\u9818\u8b80\u8005\u6aa2\u8996\u5169\u6d3e\u5c0d\u554f\u984c\u7684\u8a0e\u8ad6\uff0c\u6700\u5f8c\u518d\u63d0\u51fa\u53ef\u884c\u7684\u56e0\u61c9\u65b9\u6848\uff0c\u4e26\u5ef6\u4f38\u5176\u4ed6\u8b70\u984c\u3002\uff08\u8cac\u4efb\u7de8\u8f2f\uff1a\u9673\u6021\u541b\uff09<\/p><\/blockquote>\n<p>&nbsp;<\/p>\n<div id=\"attachment_228651\" style=\"width: 1090px\" class=\"wp-caption aligncenter\"><img aria-describedby=\"caption-attachment-228651\" loading=\"lazy\" class=\"wp-image-228651 size-full\" src=\"https:\/\/buzzorange.com\/wp-content\/uploads\/2021\/06\/laboratory-5722327_1920.jpeg\" alt=\"\" width=\"1080\" height=\"721\" \/><p id=\"caption-attachment-228651\" class=\"wp-caption-text\">(\u5716\u7247\u4f86\u6e90\uff1a<a href=\"https:\/\/pixabay.com\/zh\/users\/fernandozhiminaicela-6246704\/\">fernandozhiminaicela<\/a>)<\/p><\/div>\n<p><strong>\u3010\u7de8\u6309\u3011\u672c\u6587\u662f2.0\u7248\uff0c\u4fee\u8a02\u904e\u7a0b\u53c3\u8003\u4e86\u8a31\u591a\u4f4d\u5c08\u5bb6\u610f\u898b\uff0c\u70ba\u5c0a\u91cd\u5176\u533f\u540d\u6027\uff0c\u5728\u6b64\u4e0d\u5217\u8209\u81f4\u8b1d\u3002\u672c\u6587\u662f\u4f5c\u8005\u5011\u6574\u7406\u5206\u6790\u7684\u5fc3\u5f97\uff0c\u5e0c\u671b\u80fd\u5920\u5f15\u8d77\u66f4\u591a\u95dc\u5fc3\u548c\u8a0e\u8ad6\u3002<\/strong><\/p>\n<p><strong>\u672c\u6587\u5beb\u65bc\u570b\u7522\u9ad8\u7aef\u4e8c\u671f\u89e3\u76f2\u4e4b\u524d\uff0c\u4f46\u7121\u7919\u672c\u6587\u4e4b\u8a0e\u8ad6\uff0c\u672c\u520a\u53d6\u5f97\u4f5c\u8005\u5011\u540c\u610f\u7279\u4e88\u8f49\u8f09\uff0c\u4ee5\u4f9b\u5404\u754c\u532f\u805a\u7126\u9ede\u8207\u722d\u8b70\u4e4b\u6240\u5728\u3002<\/strong><\/p>\n<p>\u570b\u5167Covid-19\u75ab\u60c5\u7206\u767c\u4e4b\u969b\uff0c\u5169\u652f\u570b\u7522\u75ab\u82d7\u5373\u5c07\u5b8c\u6210\u4e8c\u671f\u81e8\u5e8a\u8a66\u9a57\u9001\u4ea4\u5be9\u67e5\u30025\u670828\u65e5\uff0c\u75be\u7ba1\u7f72\u548c\u5169\u5bb6\u5ee0\u5546\u7c3d\u7d04\uff1b\u653f\u5e9c\u5099\u53d7\u5716\u5229\u5ee0\u5546\u3001\u7092\u80a1\u7b49\u8cea\u7591\u3002\u8521\u82f1\u6587\u7e3d\u7d71\u4e4b\u524d\u5ba3\u5e037\u6708\u53ef\u4ee5\u65bd\u6253\u570b\u7522\u75ab\u82d7\uff1b\u5979\u57285\u670831\u65e5\u5247\u516c\u958b\u8aaa\u660e\uff0c\u570b\u7522\u75ab\u82d7\u5c07\u4ee5\u570b\u969b\u79d1\u5b78\u6a19\u6e96\u4f86\u6aa2\u9a57\u3002\u570b\u7522\u75ab\u82d7\u7684\u7814\u88fd\u727d\u6d89\u79d1\u5b78\u5c08\u696d\u3001\u570b\u6c11\u5065\u5eb7\u3001\u5168\u7403\u4eba\u9053\u95dc\u61f7\u3001\u570b\u5bb6\u5b89\u5168\u8207\u5730\u7de3\u653f\u6cbb\u7b49\u591a\u500b\u9762\u5411\uff0c\u5728\u63a2\u8a0e\u9019\u500b\u8b70\u984c\u6642\uff0c\u9700\u8981\u901a\u76e4\u601d\u7d22\u3002\u672c\u6587\u5148\u5f9e\u91ab\u5b78\u79d1\u5b78\u7684\u8ad6\u8faf\u5207\u5165\uff0c\u518d\u5ef6\u4f38\u8a0e\u8ad6\u5176\u4ed6\u8b70\u984c\u3002<\/p>\n<p>\u6211\u5011\u767c\u73fe\uff0c\u5728\u91ab\u754c\u548c\u516c\u885b\u754c\uff0c\u5c0d\u65bc\u570b\u7522\u75ab\u82d7\u4e8c\u671f\u5982\u679c\u89e3\u76f2\u6210\u529f\uff0c\u80fd\u5426\u7d66\u4e88\u7dca\u6025\u4f7f\u7528\u6388\u6b0a\uff08EUA\uff09\uff0c\u7576\u4e0b\u5206\u6210\u5169\u6d3e\uff1a\u4e00\u6d3e\u7684\u89c0\u9ede\u5805\u6301\uff0c\u81f3\u5c11\u8981\u6709\u7b2c\u4e09\u671f\u671f\u4e2d\u5206\u6790\uff08interim analysis\uff09\u8b49\u5be6\u4fdd\u8b77\u529b\u624d\u80fd\u7d66EUA\uff0c\u4f55\u6cc1\u7f8e\u570bPfizer\u3001Moderna\u3001Johnson &amp; Johnson\uff0c\u6b50\u6d32\u7684AZ\u4e5f\u90fd\u8d70\u9019\u500b\u7a0b\u5e8f\u3002<\/p>\n<p>\u53e6\u4e00\u6d3e\u7684\u89c0\u9ede\u4e3b\u5f35\uff0c\u4e8c\u671f\u8a66\u9a57\u7d50\u679c\u5018\u82e5\u4e2d\u548c\u6297\u9ad4\u6548\u50f9\u5920\u5f37\uff0c\u5373\u53ef\u8996\u540c\u5177\u6709\u4fdd\u8b77\u529b\uff0c\u4ed6\u5011\u63f4\u5f15\u767c\u8868\u5728\u300aNature Medicine\u300b\u7684\u8ad6\u6587\u70ba\u4f9d\u64da\uff0c\u4e26\u5f37\u8abf\u4e16\u754c\u885b\u751f\u7d44\u7e54\uff08WHO\uff09\u4e5f\u5728\u7814\u8a0e\u4ee5\u300c\u514d\u75ab\u6a4b\u63a5\u7814\u7a76\u300d\uff08immuno-bridging study\uff09\u53d6\u4ee3\u50b3\u7d71\u4e09\u671f\u81e8\u5e8a\u8a66\u9a57\u7684\u65b9\u6848\u2500\u2500\u65e9\u57282021\u5e741\u670828\u65e5\uff0cCOVAX\u4e3b\u8fa6\u4e00\u500b\u76f8\u5c0d\u5c0f\u578b\u7684\u8a0e\u8ad6\u6703\uff1a\u201cEmerging Challenges to the Development of Covid 19 Vaccines\u201d\uff0c\u5df2\u7d93\u63a2\u7a76\u4e86\u76f8\u95dc\u8b70\u984c\u3002\u800c\u57282021\u5e745\u670826\u65e5WHO\u8209\u8fa6\u7684\u662f\u5c08\u5bb6\u548c\u85e5\u5546\u4e00\u8d77\u53c3\u8207\u7684\u7dda\u4e0a\u6703\u8b70\u64f4\u5927\u6703\u8b70\uff1a\u201cCOVID-19 vaccines: WHO Meeting on correlates of protection\u201d\u3002\u53f0\u7063\u8207\u6703\u8005\u8f49\u8ff0\u7684\u5831\u5c0e\u898b\u300a<a href=\"https:\/\/ctee.com.tw\/news\/biotech\/467546.html?fbclid=IwAR3UkoRdnRu3omgLmCykxg3IEEilxSXSh7xfxzkYGXmH_qFHoLP4GnhPy9A\">\u5de5\u5546\u6642\u5831<\/a>\u300b\uff1b\u4ee5\u53ca\u300a<a href=\"https:\/\/www.businesstoday.com.tw\/article\/category\/183027\/post\/202106020082\/%E5%9C%8B%E7%94%A2%E7%96%AB%E8%8B%97%E6%8B%BF%E3%80%8C%E7%B7%8A%E6%80%A5%E6%8E%88%E6%AC%8A%E3%80%8D%E6%A8%99%E6%BA%96%E5%A4%AA%E5%AF%AC%E9%AC%86%EF%BC%9F%E4%B8%80%E6%96%87%E7%9C%8B%E6%87%82%E9%AB%98%E7%AB%AF%E3%80%81%E8%81%AF%E4%BA%9E%E7%94%9F%E6%8A%80%E7%96%AB%E8%8B%97%E4%BF%9D%E8%AD%B7%E5%8A%9B%E3%80%81%E5%AE%89%E5%85%A8%E6%80%A7%E9%97%9C%E9%8D%B5%E9%87%8D%E9%BB%9E\">\u4eca\u5468\u520a<\/a>\u300b\u7684\u5831\u5c0e\u63d0\u53ca\u300cWHO\u4e5f\u6b63\u5728\u7814\u64ec\u6297\u9ad4\u4fdd\u8b77\u529b\u6fc3\u5ea6COP\uff08Correlate of Protection\uff09\u4f5c\u70ba\u53d6\u4ee3\u50b3\u7d71\u7b2c3\u671f\u81e8\u5e8a\u7684\u4f5c\u6cd5\u300d\u3002<\/p>\n<p>\u70ba\u4e86\u4fbf\u65bc\u8a0e\u8ad6\uff0c\u6211\u5011\u66ab\u4e14\u628a\u524d\u8005\u7a31\u70ba\u6a19\u898f\u6d3e\uff0c\u5f8c\u8005\u7a31\u70ba\u6642\u6548\u6d3e\u3002\u6211\u5011\u5fc5\u9808\u4e8b\u5148\u8072\u660e\uff0c\u5169\u6d3e\u89c0\u9ede\u90fd\u57fa\u65bc\u79d1\u5b78\u8b49\u64da\uff0c\u90fd\u727d\u6d89\u56b4\u8085\u7684\u91ab\u5b78\u79d1\u5b78\u8207\u91ab\u5b78\u502b\u7406\u554f\u984c\uff0c\u9700\u8981\u8a8d\u771f\u770b\u5f85\u3002\u4ee5\u4e0b\uff0c\u8b93\u6211\u5011\u5148\u6aa2\u8996\u5169\u6d3e\u5c0d\u554f\u984c\u7684\u8a0e\u8ad6\uff0c\u6700\u5f8c\u518d\u63d0\u51fa\u53ef\u884c\u7684\u56e0\u61c9\u65b9\u6848\u3002<\/p>\n<h2><strong>\uff08\u4e00\uff09\u6642\u6548\u6d3e\u89c0\u9ede<\/strong><\/h2>\n<p><span style=\"color: #800000\">\u6642\u6548\u6d3e\u8a8d\u70ba\u5728\u75ab\u60c5\u7206\u767c\u7684\u7dca\u6025\u60c5\u6cc1\u4e0b\uff0c\u61c9\u63a1\u53d6\u6b0a\u5b9c\u63aa\u65bd\uff0c\u4e0d\u904e\u4ecd\u57fa\u65bc\u79d1\u5b78\u8ad6\u8b49\u8207\u8b49\u64da\u4f86\u901a\u904e\u7dca\u6025\u4f7f\u7528\u6388\u6b0a\u3002<\/span>\u4ed6\u5011\u4e3b\u5f35\uff0c\u4e2d\u548c\u6297\u9ad4\u6548\u50f9\u53ef\u4ee5\u4f5c\u70ba\u4fdd\u8b77\u529b\u7684\u66ff\u4ee3\u6307\u6a19\uff08surrogates\uff09\u3002\u6642\u6548\u6d3e\u5c0d\u570b\u7522\u75ab\u82d7\u6df1\u5177\u4fe1\u5fc3\uff0c\u8a8d\u70ba\u4e8c\u671f\u89e3\u76f2\u6210\u529f\uff0c\u5c31\u53ef\u7d66\u4e88EUA\u3002\u6642\u6548\u6d3e\u4e5f\u6307\u51faWHO\u548cCOVAX\uff08\u898b\u9644\u9304\uff09\u5df2\u7d93\u8209\u8fa6\u4e00\u7cfb\u5217\u7814\u8a0e\uff0c\u65e8\u5728\u63a2\u8a0e\u76f8\u95dc\u8b70\u984c\u3002\u6642\u6548\u6d3e\u751a\u81f3\u5ef6\u4f38\u5c0d\u570b\u7522\u9ad8\u7aef\u75ab\u82d7\u79d1\u6280\u7684\u8ad6\u8ff0\uff0c\u4ee5\u5176\u86cb\u767d\u8cea\u57fa\u5e95\uff08protein-based\uff09\u7684\u75ab\u82d7\u682a\u7531\u7f8e\u570b\u570b\u5bb6\u885b\u751f\u9662\uff08NIH\uff09\u63d0\u4f9b\uff0c\u800c\u7f8e\u570bModerna \u7684mRNA\u75ab\u82d7\u4e5f\u4f86\u81ea\u76f8\u540c\u75ab\u82d7\u682a\uff0c\u96b1\u542b\u5176\u9593\u5c31\u6709\u76f8\u8fd1\u7684\u6709\u6548\u6027\u3002<\/p>\n<p>\u7136\u5728\u91ab\u5b78\u79d1\u6280\u4e0a\uff0c\u86cb\u767d\u8cea\u57fa\u5e95\u8207mRNA\u5dee\u7570\u4e0d\u5c0f\u3002\u4e0d\u904e\uff0c\u6642\u6548\u6d3e\u50be\u5411\u8ad6\u8ff0\uff0c\u53ea\u8981\u4e8c\u671f\u81e8\u5e8a\u8a66\u9a57\u8a55\u4f30\u570b\u7522\u75ab\u82d7\u80fd\u7522\u751f\u8db3\u5920\u7684\u4e2d\u548c\u6297\u9ad4\u6548\u50f9\uff0c\u5c31\u8db3\u4ee5\u8b49\u660e\u5176\u4fdd\u8b77\u529b\uff1b\u9019\u6a23\u7684\u8aaa\u6cd5\uff0c\u4e43\u662f\u6839\u64da\u300aNature Medicine\u300b\u8ad6\u6587\u2014\u2014\u201c<a href=\"https:\/\/www.nature.com\/articles\/s41591-021-01377-8\">Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection<\/a>\u201d\u3002<\/p>\n<p>\u524d\u75be\u7ba1\u5c40\u5c40\u9577<a href=\"https:\/\/money.udn.com\/money\/story\/5612\/5499795\">\u5f35\u9d3b\u4ec1<\/a>\u5728\u8ac7\u52305\u670826\u65e5WHO\u7684\u5c08\u5bb6\u8996\u8a0a\u6703\u8b70\u6642\u6307\u51fa\uff0c\u5728\u6703\u8b70\u4e2d\u5c0d\u4e2d\u548c\u6297\u9ad4\u6548\u50f9\u548c\u4fdd\u8b77\u529b\u95dc\u806f\u4e4b\u9593\u66fe\u9032\u884c\u5ee3\u6cdb\u8a0e\u8ad6\uff0c\u4f46\u6703\u8b70\u4e26\u672a\u505a\u6210\u7d50\u8ad6\u3002\u5f35\u9d3b\u4ec1\u4e5f\u91dd\u5c0d\u70ba\u4ec0\u9ebc\u8981\u66ff\u4ee3\u800c\u4e0d\u505a\u7b2c\u4e09\u671f\uff0c\u5f15\u8ff0\u5e7e\u5927\u7406\u7531\uff1a\u300c\u4e00\u3001\u7576\u5168\u7403\u958b\u59cb\u5168\u9762\u63a5\u7a2e\u300e\u7b2c\u4e00\u4ee3\u75ab\u82d7\u300f\u4e4b\u5f8c\uff0c\u6108\u4f86\u6108\u56f0\u96e3\u9032\u884c\u50b3\u7d71\u7684\u4ee5\u5b89\u6170\u5291\u70ba\u5c0d\u7167\u7684\u96d9\u76f2\u8a66\u9a57\uff1b\u4e8c\u3001\u5168\u7403\u4e0d\u80fd\u53ea\u4f9d\u8cf4\u9019\u5e7e\u652f\u75ab\u82d7\uff0c\u5c24\u5176\u662f\u4e2d\u4f4e\u6536\u5165\u570b\u5bb6\u51b7\u93c8\u6709\u554f\u984c\uff0cmRNA\u75ab\u82d7\u5373\u4fbf\u7522\u91cf\u5920\u4e5f\u4e0d\u80fd\u666e\u53ca\uff0c\u66f4\u4f55\u6cc1\u5168\u7403\u4ecd\u4f9b\u4e0d\u61c9\u6c42\uff1b\u4e09\u3001\u82e5\u80fd\u8e29\u5728\u4e00\u4ee3\u7684\u80a9\u8180\u4e0a\u5feb\u901f\u5224\u5b9a\u6709\u6548\u7684\u4e8c\u4ee3\u75ab\u82d7\u800c\u4e0d\u70ba\uff0c\u5c0e\u81f4\u6709\u6548\u7684\u75ab\u82d7\u64fa\u8457\u4e0d\u7528\uff0c\u9019\u660e\u986f\u4e0d\u9053\u5fb7\uff1b<span style=\"color: #800000\">\u56db\u3001\u6709\u75ab\u82d7\u53ef\u63a5\u7a2e\u7684\u5730\u5340\uff0c\u7528\u300e\u5b89\u6170\u5291\u300f\u505a\u5c0d\u7167\u7d44\uff0c\u628a\u53d7\u8a66\u8005\u66dd\u9732\u5728\u88ab\u611f\u67d3\u7684\u98a8\u96aa\u4e2d\uff0c\u6709\u9055\u80cc\u91ab\u5b78\u502b\u7406\u7684\u7591\u616e\u3002<\/span>\u300d<\/p>\n<h2>\u6307\u63ee\u4e2d\u5fc3\u5c08\u5bb6\uff1a\u7d66\u570b\u7522\u75ab\u82d7\u7684\u662f\u7dca\u6025\u6388\u6b0a\uff0c\u4e0d\u662f\u6b63\u5f0f\u6388\u6b0a<\/h2>\n<p>\u76ee\u524d\u64d4\u4efb\u75ab\u60c5\u6307\u63ee\u4e2d\u5fc3\u5c08\u5bb6\u8aee\u8a62\u5c0f\u7d44\u59d4\u54e1\u7684<a href=\"https:\/\/udn.com\/news\/story\/122190\/5500526\">\u674e\u79c9\u7a4e<\/a>\u8a8d\u70ba\uff0c\u300c\u8981\u7b49\u7b2c\u4e09\u671f\uff0c\u7121\u8996\u65bc\u53f0\u7063\u73fe\u5728\u7dca\u6025\u7684\u75ab\u60c5\u3002\u4e16\u754c\u885b\u751f\u7d44\u7e54\u70ba\u4f55\u8981\u958b\u6703\u60f3\u8981\u8a02\u4fdd\u8b77\u6027\u6297\u9ad4\u6a19\u6e96\uff0c\u5c31\u662f\u8981\u8b93\u4e16\u754c\u5404\u570b\u75ab\u82d7\u5ee0\u6709\u898f\u5247\u53ef\u9075\u5faa\u3002\u7528\u8840\u6e05\u6297\u9ad4\u505a\u6548\u529b\u4fdd\u8b49\uff0c\u5df2\u7d93\u662f\u4e16\u754c\u5171\u8b58\uff0cWHO\u90fd\u8a8d\u53ef\u3002\u300d\u4ed6\u4e5f\u5f37\u8abf\uff0c\u300c\u65b0\u7684\u75ab\u82d7\u82e5\u8ddf\u76ee\u524d\u5df2\u4e0a\u5e02\u75ab\u82d7\u6bd4\u8f03\uff0c\u5982\u679c\u7522\u751f\u6297\u9ad4\u4e0d\u4e9e\u65bc\u5148\u524d\u7dca\u6025\u8a31\u53ef\u6388\u6b0a\u4e0a\u5e02\u7684\u75ab\u82d7\uff0c\u5c31\u61c9\u8a72\u7d66\u4e88\u7dca\u6025\u6388\u6b0a\uff0c<span style=\"color: #800000\">\u4f46\u9019\u662f\u7dca\u6025\u6388\u6b0a\uff0c\u4e0d\u662f\u6b63\u5f0f\u6388\u6b0a\u3002<\/span>\u300d<\/p>\n<p>\u524d\u526f\u7e3d\u7d71<a href=\"https:\/\/www.mirrormedia.mg\/story\/20210607inv011\/\">\u9673\u5efa\u4ec1<\/a>\u8fd1\u65e5\u63a5\u53d7\u8a2a\u554f\u6642\u8868\u793a\uff0c\u4e16\u754c\u885b\u751f\u7d44\u7e54\u53ec\u958b\u5c08\u5bb6\u6703\u8b70\u63a2\u8a0e\u300c\u514d\u75ab\u6a4b\u63a5\u300d\uff08immunobridging\uff09\u8a08\u756b\uff0c\u4e43\u70ba\u4e86\u300c\u8b93\u73fe\u5df2\u5b8c\u6210\u81e8\u5e8a\u4e8c\u671f\u8a66\u9a57\u7684\u75ab\u82d7\u516c\u53f8\uff0c\u53ea\u8981\u4e2d\u548c\u6297\u9ad4\u6548\u50f9\u548c\u5df2\u8a8d\u8b49\u7684\u75ab\u82d7\u4e00\u6a23\u597d\u3001\u526f\u4f5c\u7528\u4e00\u6a23\u4f4e\uff0c\u5c31\u80fd\u53d6\u5f97\u8a8d\u8b49\u3002\u300d\u7136\u800c\uff0cWHO\u57285\u670826\u65e5\u8209\u884c\u7684\u6703\u8b70\uff0c\u5c1a\u7121\u6b64\u7d50\u8ad6\uff0c\u8207\u6703\u5c08\u5bb6\u591a\u50be\u5411\u9084\u662f\u8981\u505a\u7b2c\u4e09\u671f\u8a66\u9a57\uff0c\u4f46\u4e09\u671f\u8a66\u9a57\u53ef\u904b\u7528\u300c\u514d\u75ab\u6a4b\u63a5\u300d\u6982\u5ff5\uff0c\u8a2d\u8a08\u4e0d\u540c\u65bc\u50b3\u7d71\u4e09\u671f\u7684\u81e8\u5e8a\u8a66\u9a57\u3002\u95dc\u65bc\u4e09\u671f\u300c\u514d\u75ab\u6a4b\u63a5\u300d\u7684\u8a66\u9a57\u8a2d\u8a08\uff0c\u672c\u6587\u5728\u6700\u5f8c\u56de\u61c9\u8def\u5f91\u5c07\u63d0\u53ca\u3002\u56e0\u70ba\u570b\u5167\u5a92\u9ad4\u3001\u5404\u7a2e\u793e\u5a92\u5c0d\u9019\u500b\u6703\u8b70\u5167\u5bb9\u7684\u89e3\u91cb\u773e\u8aaa\u7d1b\u7d1c\uff0c\u6709\u4e9b\u4eba\u9078\u64c7\u7279\u5b9a\u5167\u5bb9\u652f\u6301\u81ea\u8eab\u8ad6\u9ede\uff0c\u6709\u4e9b\u4eba\u4ee5\u8a1b\u50b3\u8a1b\uff0c<a href=\"https:\/\/who-e.zoom.us\/rec\/play\/r1HYTtbDvSMhFX-nqAWQHKiT-En1OegrvoMm2lU9jtKNsP28BMBCkadzQX_LOUsDA2NO542F04LEaiwg.t70xHzo_hRiWgbss?continueMode=true&amp;_x_zm_rtaid=gNrw5J_dQhmG9T4-lDO9vA.1623032057304.89f6860836d9f9a169201da704694a4f&amp;_x_zm_rhtaid=432\">\u6211\u5011\u5efa\u8b70\u6709\u8208\u8da3\u8005\u89c0\u770b\u6574\u5834\u6703\u8b70\u9304\u5f71\uff0c\u4fbf\u53ef\u4e86\u89e3\u5168\u8c8c<\/a>\uff08\u8f38\u5165passcode\uff1a\u300cJBt*NW49\u300d\u5373\u53ef\uff09\u3002<\/p>\n<p>\u6642\u6548\u6d3e\u7d93\u5e38\u5f15\u7528WHO\u7b49\u6a5f\u69cb\u7684\u6703\u8b70\u5167\u5bb9\u3002\u56e0\u6b64\uff0c\u8b93\u6211\u5011\u770b\u770b\u9019\u4e9b\u6a5f\u69cb\u6700\u8fd1\u7684\u91cd\u8981\u8a0e\u8ad6\u3002COVAX\u300c\u81e8\u5e8a\u767c\u5c55\u548c\u904b\u4f5c\u7279\u7d44\u5718\u968a\u300d\uff08Clinical Development and Operations SWAT team\uff09\u57286\u67083\u65e5\u7684\u5de5\u4f5c\u574a\u6703\u8b70\uff0c\u9032\u4e00\u6b65\u6574\u740610\u5bb6\u6b63\u5728\u57f7\u884c\u4e09\u671f\u6709\u5b89\u6170\u5291\u5c0d\u7167\u7d44\u8a66\u9a57\u516c\u53f8\uff0fNGOs\u7684\u8abf\u67e5\u5831\u544a\uff0c\u767c\u73fe\u9032\u884c\u4e09\u671f\u5b89\u6170\u5291\u5c0d\u7167\u7d44\u8a66\u9a57\u7684\u82e5\u5e72\u8ca0\u9762\u8da8\u52e2\uff0c\u5305\u62ec\u6536\u6848\u6bd4\u9810\u671f\u843d\u5f8c\u3001\u6709\u5171\u75c5\u6027\u820765\u6b72\u4ee5\u4e0a\u7fa4\u9ad4\u7684\u6536\u6848\u7387\u7279\u5225\u6162\u3001\u56e0\u8840\u6e05\u967d\u6027\u7387\u589e\u52a0\u800c\u5c0e\u81f4\u7be9\u9078\u5931\u6557\u7387\u8f03\u9ad8\u3001\u9084\u6709\u9000\u51fa\u7387\u4e5f\u589e\u9ad8\u7b49\u554f\u984c\uff08\u9019\u4e9b\u6458\u8981\u767c\u4f48\u57282021\u5e746\u67083\u65e5COVAX\u8209\u8fa6\u7684\u7814\u8a0e\u6703\uff1a\u201cBooster and Mix &amp; Match COVID-19 Vaccine Strategies Planning Ahead in an Environment of Increasing Complexity\u201d\u6240\u63d0\u4f9b\u7c21\u5831\uff0cpp.5-7\u3002\uff09\u9019\u4e9b\u65b0\u60c5\u6cc1\uff0c\u986f\u793a\u50b3\u7d71\u4e09\u671f\u81e8\u5e8a\u8a66\u9a57\u7684\u53ef\u884c\u6027\u78ba\u5be6\u9700\u8981\u91cd\u65b0\u6aa2\u8996\u3002<\/p>\n<p>\u4e0d\u904e\uff0c\u57285\uff0f26\u7684\u6703\u8b70\u88e1\uff0c\u5118\u7ba1\u90e8\u5206\u8207\u6703\u5c08\u5bb6\u9f13\u52f5\u7d0d\u5165\u4ee5\u300c\u4fdd\u8b77\u529b\u7684\u95dc\u806f\u6027\u300d\u7684\u514d\u75ab\u6a4b\u63a5\u8a66\u9a57\uff0c\u4f5c\u70ba\u514d\u9664\u50b3\u7d71\u4e09\u671f\u81e8\u5e8a\u7684\u66ff\u4ee3\u65b9\u6848\u3002\u4f46\u56e0\u65b0\u51a0\u75c5\u6bd2\u75ab\u82d7\u7522\u751f\u7684\u4e2d\u548c\u6297\u9ad4\u6548\u50f9\u5b58\u5728\u5e7e\u9ede\u57fa\u672c\u56f0\u5883\uff1a<\/p>\n<blockquote><p>\uff081\uff09\u6aa2\u6e2c\u4e26\u6c92\u6709\u88ab\u6a19\u6e96\u5316\uff1b<\/p>\n<p>\uff082\uff09\u5c1a\u672a\u6709\u4eba\u985e\u6311\u6230\u7814\u7a76\uff08human challenge study\uff09\u6578\u64da\uff1b<\/p>\n<p>\uff083\uff09\u4e5f\u6c92\u6709\u95dc\u65bc\u6297\u9ad4\u548c\u98a8\u96aa\u7684\u9577\u671f\u6578\u64da\uff08Davenport, Miles, 2021. \u201cImmune Protection from SARS-Cov-2.\u201d Presented at WHO meeting on 5\/26\uff09\u3002\u56e0\u70ba\u9019\u4e9b\u56f0\u5883\uff0c\u4e5f\u8a31\u540c\u4e00\u500b\u5e73\u53f0\u75ab\u82d7\uff08\u6bd4\u5982BNT\u7684\u7b2c\u4e00\u4ee3\u548c\u7b2c\u4e8c\u4ee3\uff09\u6bd4\u8f03\u554f\u984c\u6bd4\u8f03\u5c0f\uff0c\u4f46\u5c0d\u8de8\u5e73\u53f0\u75ab\u82d7\u6bd4\u8f03\uff08\u4f8b\u5982\u5728Moderna\u548cAstraZeneca\u4e4b\u9593\u505a\u6bd4\u8f03\uff09\uff0c\u5247\u77ed\u671f\u5167\u56e0\u70ba\u7f3a\u4e4f\u6578\u64da\uff0c\u96e3\u5ea6\u5c31\u8f03\u9ad8\u3002<\/p><\/blockquote>\n<p>\u6b64\u5916\uff0c\u73fe\u5728\u4e16\u754c\u5404\u570b\u9678\u7e8c\u51fa\u73fe\u8b8a\u7a2e\u75c5\u6bd2\uff0c\u5982\u4f55\u52a0\u901f\u6838\u51c6\u65b0\u75ab\u82d7\u4e43\u523b\u4e0d\u5bb9\u7de9\u7684\u8ab2\u984c\u3002COVAX\u57282021\u5e743\u670825\u65e5\u8209\u8fa6\u7814\u8a0e\u6703\uff0c\u4e3b\u8981\u805a\u7126\u8b8a\u7a2e\u75c5\u6bd2\u7814\u767c\u6539\u826f\u75ab\u82d7\u7b49\u8b70\u984c\uff0cFlores\u7b49\u4eba\u91dd\u5c0d\u8b8a\u7a2e\u75c5\u6bd2\u75ab\u82d7\u7684\u5be9\u6838\u9014\u5f91\u6307\u51fa\uff0c\u514d\u75ab\u6a4b\u63a5\uff08immune-bridging\uff09\u53ef\u70ba\u6c92\u7372\u6279\u51c6\u539f\u578b\u75ab\u82d7\u7684\u5ee0\u5546\uff0c\u63d0\u4f9b\u6f5b\u5728\u5feb\u901f\u751f\u7522\u65b0\u7684\u6539\u826f\u75ab\u82d7\u7684\u901a\u9053\uff0c\u5c24\u5176\u6539\u826f\u75ab\u82d7\u6b78\u5c6c\u5728\u5df2\u7372\u6279\u51c6\u539f\u578b\u75ab\u82d7\u7684\u540c\u985e\uff08precedented class\uff09\u4e2d\u2014\u2014\u5982Moderna\u7b2c\u4e00\u4ee3\u548c\u7b2c\u4e8c\u4ee3\u3002\u4ed6\u5011\u63d0\u51fa\u8f14\u52a9\u65b0\u75ab\u82d7\u5feb\u901f\u901a\u9053\u7684\u5e7e\u500b\u65b9\u91dd\uff1a<\/p>\n<blockquote><p>\uff081\uff09\u63a5\u53d7\u7684\u53ef\u80fd\u6027\u53d6\u6c7a\u65bc\u65b0\u7684\u5019\u9078\u6539\u826f\u75ab\u82d7\u8207\u63d0\u4f9b\u6a4b\u63a5\u7684\u5df2\u7372\u6279\u51c6\u539f\u578b\u75ab\u82d7\u4e4b\u9593\u7684\u5dee\u7570\u5ea6\u3002<\/p>\n<p>\uff082\uff09\u9700\u8981\u8db3\u5920\u5927\u7684\u5b89\u5168\u6027\u8cc7\u6599\u5eab\u3002<\/p>\n<p>\uff083\uff09\u6279\u51c6\u5f8c\u7684\u85e5\u7269\u76e3\u63a7\u548c\u6709\u6548\u6027\u7814\u7a76\u61c9\u5728\u8a08\u756b\u5f15\u5165\u6642\u5c31\u555f\u52d5\u3002<\/p>\n<p>\uff084\uff09\u5728\u514d\u75ab\u6a4b\u63a5\u7121\u6cd5\u88ab\u63a5\u53d7\u7684\u60c5\u6cc1\u4e0b\uff0c<br \/>\n\uff08a\uff09\u53ef\u7528\u7d93\u6279\u51c6\u7684\u6539\u826f\u75ab\u82d7\u4f5c\u70ba\u6bd4\u8f03\u57fa\u6e96\uff08comparator\uff09\uff0c\u800c\u300c\u975e\u52a3\u6027\u85e5\u6548\u7814\u7a76\u300d\uff08non inferiority efficacy studies\uff09\u53ef\u80fd\u662f\u6700\u4f73\u9078\u64c7\uff08\u6309\uff1a\u6307\u6539\u826f\u75ab\u82d7\u7684\u7642\u6548\u662f\u512a\u65bc\u6216\u7b49\u65bc\u73fe\u5b58\u75ab\u82d7\u4f5c\u70ba\u70ba\u63a7\u5236\u7d44\u7684\u7642\u6548\uff09\uff1b\u4f46\u7814\u7a76\u898f\u6a21\u53ef\u80fd\u4e0d\u53ef\u884c\uff1b<br \/>\n\uff08b\uff09\u6c92\u6709\u5df2\u6279\u51c6\u7684\u75ab\u82d7\u5c0d\u8b8a\u7a2e\u6709\u660e\u986f\u7642\u6548\uff0c\u90a3\u9ebc\u81e8\u5e8a\u7642\u6548\u8a66\u9a57\u8a2d\u8a08\u5c07\u53d6\u6c7a\u65bc\u6d41\u884c\u7684\u75c5\u6bd2\u682a\u548c\u73fe\u6709\u4f5c\u70ba\u6bd4\u8f03\u57fa\u6e96\u7684\u5df2\u6279\u51c6\u539f\u578b\u75ab\u82d7\u7684\u7642\u6548\uff1b\u5728\u5c11\u6578\u60c5\u6cc1\u4e0b\uff0c\u9032\u884c\u5b89\u6170\u5291\u5c0d\u7167\u8a66\u9a57\u53ef\u80fd\u662f\u53ef\u884c\u7684\uff08Flores, Jorge, Margaret Toher and David Kaslow, 2021. \u201cPathways for Approval of COVID-19 Vaccines Based on SARS CoV 2 Variant Strains,\u201d presented on \u201cSARS-CoV2 variants Practical considerations for accelerated clinical development in light of current regulatory guidance,\u201d Clinical Development &amp; Operations SWAT Team, sponsored by CEPI, GAVI, WHO, and UNICEF, March 25.\uff09\u3002<\/p><\/blockquote>\n<p>\u5728\u76ee\u524d\u5168\u7403\u75ab\u60c5\u4e0b\uff0c\u7b2c\u4e09\u671f\u81e8\u5e8a\u8a66\u9a57\u7684\u96e3\u5ea6\u6108\u4f86\u6108\u9ad8\uff08\u5305\u62ec\u502b\u7406\u554f\u984c\u3001\u4eba\u53e3\u4e2d\u8840\u6e05\u967d\u6027\u7387\u5927\u91cf\u589e\u52a0\u7b49\u56e0\u7d20\uff09\uff0c\u900f\u904e\u514d\u75ab\u6a4b\u63a5\u8a66\u9a57\u4f86\u4ee3\u66ff\u75ab\u82d7\u6548\u529b\uff0c\u7684\u78ba\u662f\u76ee\u524d\u6700\u65b0\u75ab\u60c5\u4e0b\u7684\u4e00\u500b\u66ff\u4ee3\u65b9\u6cd5\u3002\u53f0\u7063\u98df\u85e5\u7f72\u4e5f\u4f7f\u7528\u8207\u4e0a\u8ff0\u76f8\u540c\u7684\u539f\u5247\u5728\u9762\u5c0d\u570b\u7522\u75ab\u82d7\u7684EUA\u3002\u6642\u6548\u6d3e\u7684\u514d\u75ab\u6a4b\u63a5\u8ad6\u9ede\u7b97\u662f\u4ea6\u6b65\u4ea6\u8da8\u8ddf\u8457WHO\u7684\u8a0e\u8ad6\uff0c\u5118\u7ba1\u9019\u4e9b\u8a0e\u8ad6\u5c1a\u672a\u6210\u70baWHO\u5b98\u65b9\u7684\u6b63\u5f0f\u63d0\u6848\u3002<\/p>\n<h2><strong>\uff08\u4e8c\uff09\u6a19\u898f\u6d3e\u89c0\u9ede<\/strong><\/h2>\n<p>\u6a19\u898f\u6d3e\u4e3b\u5f35\u8005\u4e2d\uff0c<a href=\"https:\/\/forum.ettoday.net\/news\/1933514\">\u53f0\u5927\u91ab\u9662\u81e8\u5e8a\u8a66\u9a57\u4e2d\u5fc3\u4e3b\u4efb\u9673\u5efa\u7152\u5f88\u5177\u4ee3\u8868\u6027\u3002\u4ed6\u5728\u4eca\u5e74\u4e09\u6708\u5beb\u7684\u4e00\u7bc7\u6587\u7ae0<\/a>\u5ee3\u70ba\u6d41\u50b3\uff1a\u300c\u65bd\u6253\u75ab\u82d7\u5f8c\uff0c\u4eba\u9ad4\u7684\u514d\u75ab\u7cfb\u7d71\u6703\u7522\u751f\u4e2d\u548c\u6297\u9ad4\u53ca\u8a31\u591a\u7684\u7d30\u80de\u53cd\u61c9\u4f86\u5c0d\u6297\u75c5\u6bd2\uff0c\u5728\u9019\u4e9b\u5c0d\u6297\u75c5\u6bd2\u7684\u6b66\u5668\u4e2d\uff0c\u4e2d\u548c\u6297\u9ad4\u6bd4\u7d30\u80de\u53cd\u61c9\u5bb9\u6613\u6e2c\u91cf\uff0c\u6545\u88ab\u8996\u70ba\u4e00\u500b\u66ff\u4ee3\u7684\u7642\u6548\u6307\u6a19\uff08surrogate end point\uff09\uff0c\u7136\u800c\u300e\u65bd\u6253\u75ab\u82d7\u3001\u6709\u7522\u751f\u4e2d\u548c\u6297\u9ad4\u300f\u5c31\u7b49\u65bc\u300e\u6349\u5230\u8001\u9f20\u300f\u4e86\u55ce\uff1f\u61c9\u8a72\u4e0d\u662f\uff01<span style=\"color: #800000\">\u66f4\u91cd\u8981\u7684\u662f\u80fd\u9810\u9632\u6709\u81e8\u5e8a\u75c7\u72c0\u7684\u65b0\u51a0\u80ba\u708e<\/span>\uff0c\u7279\u5225\u662f\u91cd\u75c7\uff08\u8981\u4f4f\u52a0\u8b77\u75c5\u623f\u3001\u7528\u547c\u5438\u5668\u3001\u8449\u514b\u819c\u6216\u6b7b\u4ea1\uff09\uff1b<span style=\"color: #800000\">\u56e0\u6b64\u5148\u9032\u570b\u5bb6\u5982\u82f1\u570b\u3001\u7f8e\u570b\u53ca\u6b50\u76df\u7684\u85e5\u653f\u7ba1\u7406\u55ae\u4f4d\u6838\u51c6\u75ab\u82d7\u7dca\u6025\u4f7f\u7528\u6388\u6b0a\uff08EUA\uff09\u7684\u689d\u4ef6\uff0c\u4e26\u4e0d\u662f\u4e2d\u548c\u6297\u9ad4\u7684\u7522\u751f\uff0c\u800c\u662f\u5fc5\u9808\u770b\u5230\u75ab\u82d7\u80fd\u6709\u6548\u5730\u9810\u9632\u6709\u81e8\u5e8a\u75c7\u72c0\u7684\u65b0\u51a0\u80ba\u708e<\/span>\u3002\u2026\u2026\u91ab\u5b78\u6587\u737b\u53ca\u91ab\u7642\u7522\u54c1\u767c\u5c55\u904e\u7a0b\u4e2d\u300e\u7406\u8ad6\u4e0a\u6709\u6548\u3001\u521d\u671f\u4eba\u9ad4\u8a66\u9a57\u6709\u6548\uff0c\u4f46\u5927\u898f\u6a21\u81e8\u5e8a\u8a66\u9a57\u767c\u73fe\u662f\u7121\u6548\u6216\u6709\u5bb3\u300f\u7684\u6848\u4f8b\u592a\u591a\u4e86\uff0c\u518d\u5177\u6709\u5438\u5f15\u529b\u7684\u7406\u8ad6\uff0c\u9084\u662f\u9700\u8981\u5927\u898f\u6a21\u81e8\u5e8a\u8a66\u9a57\u52a0\u4ee5\u9a57\u8b49\uff0c\u9019\u624d\u662f\u8fd1\u4ee3\u5be6\u8b49\u91ab\u5b78\u7684\u7cbe\u795e\u3002\u300d<\/p>\n<h2>\u7d66\u570b\u7522\u75ab\u82d7\u7dca\u6025\u6388\u6b0a\u4e0d\u662f\u4e0d\u53ef\u4ee5\uff0c\u4f46\u61c9\u8a72\u6e05\u695a\u8aaa\u660e\u6838\u51c6\u7684\u6a19\u6e96\u662f\u4ec0\u9ebc<\/h2>\n<p>\u6700\u8fd1\uff0c<a href=\"https:\/\/forum.ettoday.net\/news\/1995597?from=rss&amp;redirect=1\">\u9673\u5efa\u7152<\/a>\u91cd\u7533\u61c9\u4ee5\u4e09\u671f\u8a66\u9a57\u671f\u4e2d\u5206\u6790\u70ba\u57fa\u6e96\uff1a\u300c<span style=\"color: #800000\">\u5f9e2020\u5e74\u5e95\u81f3\u4eca\uff0c\u5148\u9032\u570b\u5bb6\u53caWHO\u6838\u51c6\u7dca\u6025\u4f7f\u7528\u7684\u65b0\u51a0\u80ba\u708e\u75ab\u82d7\uff0c\u90fd\u662f\u7528\u4e09\u671f\u8a66\u9a57\u7684\u671f\u4e2d\u5206\u6790\u6578\u64da\u3001\u5be6\u8b49\u652f\u6301\u53ef\u9810\u9632\u81e8\u5e8a\u75be\u75c5\u70ba\u57fa\u6e96\uff0c\u53f0\u7063\u8981\u7528\u66f4\u5bec\u9b06\u7684\u6a19\u6e96\uff0c\u4f86\u7d66\u570b\u7522\u75ab\u82d7\u7dca\u6025\u6388\u6b0a\u4e0d\u662f\u4e0d\u53ef\u4ee5\uff0c\u4f46\u61c9\u8a72\u6e05\u695a\u8aaa\u660e\uff0c\u6211\u5011\u6838\u51c6\u7684\u6a19\u6e96\u662f\u4ec0\u9ebc\uff1f\u4e0d<\/span>\u540c\u5c08\u5bb6\u5c0d\u65bc\u9019\u8ab2\u984c\u6709\u4e0d\u540c\u610f\u898b\uff0c\u516c\u958b\u900f\u660e\u624d\u80fd\u53d6\u5f97\u79d1\u5b78\u793e\u7fa4\u7684\u4fe1\u4efb\u3002\u300d\u300c\u65b0\u51a0\u80ba\u708e\u662f\u65b0\u8208\u75be\u75c5\uff0c\u548c\u6d41\u611f\u3001A\u578b\u809d\u708e\u7b49\u5df2\u7814\u7a76\u591a\u5e74\u7684\u75be\u75c5\u4e0d\u540c\uff0c\u96d6\u7136\u5f88\u6176\u5e78\u6709\u6578\u500b\u65b0\u51a0\u80ba\u708e\u75ab\u82d7\u5df2\u7814\u767c\u6210\u529f\uff0c\u4f46\u4e2d\u548c\u6297\u9ad4\u6578\u64da\u4ecd\u5728\u5206\u6790\u4e2d\uff0c\u73fe\u5728\u4e0d\u5b9c\u5984\u4e0b\u7d50\u8ad6\u3002\u300d<\/p>\n<p>\u57fa\u672c\u4e0a\uff0c\u300c\u76f8\u540c\u75c5\u6bd2\u682a\u300d\u662f\u63f4\u5f15\u751f\u7269\u76f8\u4f3c\u6027\uff08biosimilarity\uff09\u7684\u539f\u7406\u3002\u514d\u75ab\u6a4b\u63a5\u8a66\u9a57\u662f\u770b\u7522\u751f\u6297\u9ad4\u7684\u751f\u7269\u76f8\u4f3c\u6027\u53cd\u61c9\uff0c\u4f46\u9664\u4e86\u6297\u9ad4\u4ee5\u5916\uff0c\u81e8\u5e8a\u4fdd\u8b77\u529b\u4ecd\u9700\u8003\u91cfT\u7d30\u80de\uff08T-cell\uff09\u7684\u53cd\u61c9\u3002\u6642\u6548\u6d3e\u5f37\u8abf\u514d\u75ab\u6a4b\u63a5\uff0c\u4f46\u5c0d\u4e0d\u540c\u5ee0\u724c\uff08\u5e73\u53f0\uff09\u7684\u75ab\u82d7\uff0c\u570b\u969b\u6a19\u6e96\u4ecd\u9700\u6709\u81e8\u5e8a\u7642\u6548\uff08clinical outcome\uff09\u6307\u6a19\u3002<a href=\"https:\/\/www.fda.gov\/media\/144416\/download#page6\">\u7f8e\u570bFDA\u5728\u53bb\u5e74\u5341\u4e00\u6708\u5e95\u6838\u51c6Pfizer\/BNT\u75ab\u82d7\u7684EUA\u516c\u544a\uff0c\u7b2c\u516d\u9801\u57f7\u884c\u6458\u8981<\/a>\uff08executive summary\uff09\u6709\u8a73\u8ff0\u53c3\u8207\u4e09\u671f\u81e8\u5e8a\u8a66\u9a57\u7684\u4eba\u6578\u548c\u6548\u529b\u53ca\u5b89\u5168\u6027\u5224\u5b9a\u7684\u6a19\u6e96\uff0c\u5747\u8d85\u904e\u4e09\u842c\u9918\u4eba\u3002\u7f8e\u570bFDA\u7684\u7dca\u6025\u6388\u6b0a\u7684\u78ba\u4f9d\u64da\u671f\u4e2d\u5206\u6790\u7684\u7d50\u679c\uff0c\u9019\u5927\u6982\u662f\u300c\u672a\u5b8c\u6210\u4e09\u671f\u81e8\u5e8a\u8a66\u9a57\u300d\u7684\u8aaa\u6cd5\u4f86\u6e90\uff0c\u4f46\u82e5\u8b1b\u6210\u300c\u672a\u7d93\u81e8\u5e8a\u4e09\u671f\u8a66\u9a57\u5c31\u6279\u51c6EUA\u300d\uff0c\u5247\u662f\u8aa4\u5c0e\u3002\u7b2c\u4e09\u671f\u81e8\u5e8a\u8a66\u9a57\u9032\u884c\u671f\u4e2d\u5206\u6790\u662f\u70ba\u8003\u91cf\u7642\u6548\u53ca\u5b89\u5168\u6027\u7684\u76e3\u6e2c\u6703\u8b70\uff0c\u660e\u8a02\u63d0\u65e9\u7d50\u675f\u4e4b\u898f\u5b9a\uff08stopping rule\uff09\uff0c\u7531\u5ee0\u5546\u63d0\u7d66FDA\u3002<\/p>\n<p>\u5047\u82e5\u4e0d\u8d70\u6b63\u898f\u4e09\u671f\u8def\u5f91\uff0c\u9664\u4e86\u514d\u75ab\u6a4b\u63a5\u8a66\u9a57\uff0c\u9084\u6709\u201cNon inferiority trials with disease endpoint\u201d\uff08\u975e\u52a3\u6027\u8a66\u9a57\uff09\u53ef\u64cd\u4f5c\uff0c\u5c31\u662f\u5728\u4e09\u671f\u8a66\u9a57\u4e2d\uff0c\u5c0d\u7167\u7d44\u4e0d\u7528placebo\uff0c\u800c\u4ee5\u65e2\u6709EUA\u7684\u75ab\u82d7\u4f5c\u70ba\u5c0d\u7167\u7d44\uff0c\u770b\u65b0\u75ab\u82d7\u7684\u4fdd\u8b77\u529b\u662f\u5426\u4e0d\u4e9e\u65bc\u65e2\u6709\u75ab\u82d7\uff08new vaccine is not appreciably worse than licensed vaccine\uff09\uff0c\u5982\u679c\u904e\u95dc\uff0c\u5373\u53efEUA\u3002\u9019\u500b\u63d0\u8b70\u7531Dean Follmann\u57282021\u5e741\u670828\u65e5COVAX\u7684\u7814\u8a0e\u6703\u4e2d\u63d0\u51fa\uff08P. 32 in \u201cLicensure of New Vaccines Going Forward,\u201d presented by Dean Follmann on \u201cEmerging Challenges to the Development of Covid 19 Vaccines,\u201d Clinical Development &amp; Operations SWAT Team, January 28, 2021sponsored by Covax, CEPI, GAVI, and WHO.\uff09\u3002\u4e0a\u8ff0COVAX\u5728\u4eca\u5e743\u6708\u7684\u7814\u8a0e\u6703\u8b70\u4e5f\u5982\u6b64\u5efa\u8b70\u3002\u82e5\u63a1\u53d6\u975e\u52a3\u6027\u8a66\u9a57\u7814\u7a76\u8def\u5f91\uff0c\u5c31\u53ef\u4ee5\u907f\u958b\u6642\u6548\u6d3e\u6240\u8aaa\u300c\u5728\u76db\u884c\u5340\u65bd\u6253\u5b89\u6170\u5291\u4e0d\u7b26\u5408\u502b\u7406\u7684\u96e3\u984c\u300d\u3002<\/p>\n<p>\u7f8e\u570b\u653f\u5e9c\u5728SARS\u3001MERS\u3001Ebola\u3001\u8332\u5361\u75c5\u6bd2\u7206\u767c\u5f8c\uff0c\u5c31\u6aa2\u8a0e\u904e\u500b\u4eba\u9632\u8b77\u8a2d\u5099\uff08PPE\uff09\u4e0d\u8db3\u4ee5\u4f5c\u70ba\u63a7\u5236\u7684\u65b9\u6cd5\uff0c\u800c\u671d\u5411\u767c\u5c55\u75ab\u82d7\u30022017\u5e74\u806f\u90a6\u5236\u5b9a\u65b0\u6cd5\u898f\uff0c\u57fa\u65bc\u570b\u5b89\u7406\u7531\uff0cNIH\u9f13\u52f5\u958b\u767c\u751f\u7269\u88fd\u5291\uff0c\u5305\u62ecmRNA\u7814\u7a76\u3002Covid-19\u7206\u767c\u4e4b\u5f8c\uff0cFDA\u66fe\u7d93\u5c0dEUA\u6307\u5c0e\u539f\u5247\u505a\u904e\u6578\u6b21\u8abf\u6574\uff0c\u7b2c\u4e00\u6b21\u57282020\u5e7411\u6708\uff0c\u7b2c\u4e8c\u6b21\u57282021\u5e742\u670822\u65e5\uff0c\u7b2c\u4e09\u6b21\uff08\u4e5f\u662f\u6700\u65b0\u4e00\u6b21\uff09\u57282021\u5e745\u670825\u65e5\u30022020\u5e7411\u6708\u8abf\u6574\u7576\u521d\uff0c\u6709\u91dd\u5c0d\u6838\u51c6EUA\u7684\u6a19\u6e96\u505a\u82e5\u5e72\u4fee\u6539\u3002\u4f46\u662f\uff0c\u5f8c\u4f86\u7f8e\u570b\u5e7e\u652f\u65b0\u51a0\u80ba\u708e\u75ab\u82d7\u7372\u5f97EUA\uff0c\u90fd\u63a1\u53d6\u6b63\u898f\u7a0b\u5e8f\uff1a\u4ea6\u5373\uff0c\u90fd\u662f\u4e09\u671f\u671f\u4e2d\u5831\u544a\u901a\u904eFDA\u5be9\u67e5\uff0c\u800c\u7372\u5f97EUA\uff0c\u5176\u4e2dPfizer, Moderna, Johnson &amp; Johnson\u90fd\u8d70\u5b8c\u9019\u500b\u7a0b\u5e8f\u3002\u96d6\u7136\uff0c\u63a1\u7528\u4e2d\u548c\u6297\u9ad4\u6548\u50f9\u4f5c\u70ba\u4fdd\u8b77\u529b\u76f8\u95dc\u6027\u7684\u6307\u6a19\uff0c\u5728\u5176\u4ed6\u75ab\u82d7\u90fd\u6709\u5be6\u4f8b\uff0c\u4f8b\u5982B\u809d\u75ab\u82d7\u548c\u6d41\u611f\u75ab\u82d7\uff0c\u9019\u4e43\u4f7f\u7528\u751f\u7269\u76f8\u4f3c\u6027\u7684\u539f\u7406\u3002\u4f46\u662f\u65b0\u51a0\u80ba\u708e\u662f\u65b0\u7684\u75be\u75c5\uff0c\u6050\u96e3\u76f4\u63a5\u5957\u7528\uff0c\u56e0\u70ba\u55ae\u662fT-cell\u53cd\u61c9\u7684\u5b9a\u91cf\u70ba\u4f55\uff0c\u5c31\u6c92\u6709\u8db3\u5920\u7684\u8cc7\u6599\uff0c\u66f4\u9051\u8ad6\u5176\u4ed6\u3002<\/p>\n<p><strong>\u9644\u9304\uff1a COVAX\uff08COVID-19 Vaccines Global Access\u56b4\u91cd\u7279\u6b8a\u50b3\u67d3\u6027\u80ba\u708e\u75ab\u82d7\u5be6\u65bd\u8a08\u5283\uff09\u57282020\u5e74\u4e0a\u534a\u5e74\u6210\u7acb\u300c<a href=\"https:\/\/epi.tghn.org\/covax-overview\/clinical-science\/\">\u81e8\u5e8a\u767c\u5c55\u548c\u904b\u4f5c\u7279\u7d44\u5718\u968a<\/a>\u300d\uff08Clinical Development and Operations SWAT team\uff09\uff0c\u5c08\u9580\u8655\u7406\u81e8\u5e8a\u958b\u767c\u548c\u904b\u4f5c\u7b49\u76f8\u95dc\u8b70\u984c\uff0c\u5305\u62ec\u652f\u6301\u81e8\u5e8a\u8a66\u9a57\u5834\u57df\u7684\u6e96\u5099\u548c\u5efa\u7acb\u5176\u9593\u7db2\u7d61\uff0c\u4e5f\u7814\u8a0e\u75ab\u82d7\u5b89\u5168\u548c\u75ab\u82d7\u79d1\u5b78\u7b49\u3002\u76ee\u524d\u95dc\u65bc\u65b0\u51a0\u80ba\u708e\u6700\u524d\u6cbf\u7814\u8a0e\uff0c\u591a\u534a\u7531\u9019\u500b\u5718\u968a\u5148\u900f\u904e\u5de5\u4f5c\u574a\u767c\u52d5\u8b70\u984c\uff0c\u518d\u919e\u91c0\u6210\u70ba\u4e16\u754c\u885b\u751f\u7d44\u7e54\u548c\u5176\u4ed6\u570b\u5bb6\u7684\u5171\u8b58\u3002\u9019\u500b\u5de5\u4f5c\u574a\u6bcf\u6708\u5b9a\u671f\u958b\u4e00\u6b21\u6703\uff0c\u95dc\u65bc\u958b\u6703\u4e3b\u984c\u3001\u6703\u8b70\u5831\u544a\u3001\u5de5\u4f5c\u574a\u8a0e\u8ad6\u7d20\u6750\u7684PPT\u3001\u5de5\u4f5c\u574a\u7684\u554f\u8207\u7b54\uff0c\u6216\u662f\u6703\u5f8c\u8ad6\u58c7\uff0c\u90fd\u767c\u4f48\u5728\u5176\u5c08\u5c6c\u7db2\u9801\u3002\u5efa\u8b70\u95dc\u6ce8\u76f8\u95dc\u8b70\u984c\u7684\u653f\u5e9c\u55ae\u4f4d\u3001\u5ee0\u5546\u3001\u7814\u7a76\u8005\u3001\u5a92\u9ad4\u3001\u8207\u5927\u773e\u4e0a\u7db2\u67e5\u8a62\u3002\u7576\u6211\u5011\u5728\u95b1\u8b80\u7db2\u7ad9\u4e0b\u8f09\u6587\u4ef6\uff0c\u6703\u767c\u73fe\u5c01\u9762\u6709\u6d41\u884c\u75c5\u9632\u7bc4\u5275\u65b0\u806f\u76df\uff08CEPI\uff09\u3001\u75ab\u82d7\u806f\u76df\uff08Gavi\uff09\u3001\u4e16\u754c\u885b\u751f\u7d44\u7e54\uff08WHO\uff09\u3001\u806f\u5408\u570b\u5152\u7ae5\u57fa\u91d1\u6703\uff08UNICEF\uff09\u7684\u6a19\u8a8c\uff0c\u4e43\u7de3\u65bcCOVAX \u6700\u65e9\u7531\u4e0a\u8ff0\u7d44\u7e54\u767c\u52d5\u7d44\u6210\uff0c\u76ee\u524d\u6709 192\u500b\u570b\u5bb6\u53c3\u8207\u5176\u4e2d\uff1b\u800c\u300c\u81e8\u5e8a\u767c\u5c55\u548c\u904b\u4f5c\u7279\u7d44\u5718\u968a\u300d\u96b8\u5c6cCOVAX \uff0c\u4e0d\u904e\u6bcf\u6b21\u53c3\u8207\u5de5\u4f5c\u574a\u8a0e\u8ad6\u7684\u5c08\u5bb6\u5247\u6839\u64da\u8b70\u984c\u6642\u6709\u8b8a\u52d5\u3002<\/strong><\/p>\n<h2>\u63a8\u85a6\u95b1\u8b80<\/h2>\n<p><a href=\"https:\/\/buzzorange.com\/2021\/06\/11\/hospital-epidemic-civid-19\/\">\u30104\u6210\u7f8e\u570b\u4eba\u66fe\u56e0\u9867\u616eCOVID-19 \u5ef6\u5f8c\u5c31\u91ab\u3011\u7576\u5c40\u8acb\u6ce8\u610f\u75ab\u60c5\u4e0b\uff0c\u6240\u9020\u6210\u7684\u300c\u63a8\u9072\u5c31\u91ab\u6548\u61c9\u300d\uff01<\/a><\/p>\n<p><a href=\"https:\/\/buzzorange.com\/2021\/06\/10\/taiwan-cdc-vaccine\/?fbclid=IwAR07As0S6zNRbWX5kdtK3-kYJG2nyMBwKo72MHpo-Oy7EDvfSHwu6QcoPHQ\">\u3010\u6b0a\u8cb4\u6436\u6253\u75ab\u82d7\u800d\u7279\u6b0a\uff0c\u75ab\u82d7\u6c92\u6709\u6211\u7684\u4efd\uff01\u3011\u6307\u63ee\u4e2d\u5fc3\u9700\u4f9d\u6cd5\u91cd\u7f70\uff0c\u65b9\u80fd\u627e\u56de\u516c\u4fe1\u529b<\/a><\/p>\n<p><a href=\"https:\/\/buzzorange.com\/2021\/06\/08\/korea-vaccine\/\">\u3010\u5831\u6a58\u5e36\u4f60\u770b\uff1a\u5404\u570b\u75ab\u82d7\u65bd\u6253\u65b9\u91dd\u3011\u9996\u723e\u5e02\u63a8\u300c333 \u5c0d\u7b56\u300d\uff0c\u7642\u990a\u9662\u9662\u6c11\u53ca\u5f9e\u696d\u4eba\u54e1\u7b2c\u4e00\u68af\u5148\u6253<\/a><\/p>\n<p>\uff08\u672c\u6587\u7d93\u5408\u4f5c\u5925\u4f34 \u601d\u60f3\u5766\u514b \u6388\u6b0a\u8f49\u8f09\uff0c\u4e26\u540c\u610f BuzzOrange \u7de8\u5beb\u5c0e\u8b80\u8207\u4fee\u8a02\u6a19\u984c\uff0c\u539f\u6587\u6a19\u984c\u70ba <a href=\"https:\/\/voicettank.org\/%E5%9C%8B%E7%94%A2%E7%96%AB%E8%8B%97%E7%B7%8A%E6%80%A5%E4%BD%BF%E7%94%A8%E6%8E%88%E6%AC%8A%E7%88%AD%E8%AD%B0%E8%88%87%E5%9B%A0%E6%87%89%E8%B7%AF%E5%BE%91%E4%B8%8A\/\">\u3008\u570b\u7522\u75ab\u82d7\u7dca\u6025\u4f7f\u7528\u6388\u6b0a\u722d\u8b70\u8207\u56e0\u61c9\u8def\u5f91\uff08\u4e0a\uff09\u3009<\/a>\u3002\u9996\u5716\u4f86\u6e90\uff1a<a href=\"https:\/\/pixabay.com\/zh\/users\/fernandozhiminaicela-6246704\/\">fernandozhiminaicela<\/a>)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\uff08\u672c\u6587\u7d93\u5408\u4f5c\u5925\u4f34 \u601d\u60f3\u5766\u514b \u6388\u6b0a\u8f49\u8f09\uff0c\u4e26\u540c\u610f BuzzOrange \u7de8\u5beb\u5c0e\u8b80\u8207\u4fee\u8a02\u6a19\u984c\uff0c\u539f\u6587\u6a19\u984c\u70ba \u3008\u570b\u7522\u75ab\u82d7\u7dca\u6025\u4f7f\u7528\u6388\u6b0a\u722d\u8b70\u8207\u56e0\u61c9\u8def\u5f91\uff08\u4e0a\uff09\u3009\u3002\u9996\u5716\u4f86\u6e90\uff1afernandozhiminaicela)[&#8230;]<\/p>\n","protected":false},"author":5,"featured_media":19393,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[105,108,39],"_links":{"self":[{"href":"https:\/\/buzzorange.com\/citiorange\/wp-json\/wp\/v2\/posts\/196"}],"collection":[{"href":"https:\/\/buzzorange.com\/citiorange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buzzorange.com\/citiorange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buzzorange.com\/citiorange\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/buzzorange.com\/citiorange\/wp-json\/wp\/v2\/comments?post=196"}],"version-history":[{"count":1,"href":"https:\/\/buzzorange.com\/citiorange\/wp-json\/wp\/v2\/posts\/196\/revisions"}],"predecessor-version":[{"id":33897,"href":"https:\/\/buzzorange.com\/citiorange\/wp-json\/wp\/v2\/posts\/196\/revisions\/33897"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buzzorange.com\/citiorange\/wp-json\/wp\/v2\/media\/19393"}],"wp:attachment":[{"href":"https:\/\/buzzorange.com\/citiorange\/wp-json\/wp\/v2\/media?parent=196"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buzzorange.com\/citiorange\/wp-json\/wp\/v2\/categories?post=196"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buzzorange.com\/citiorange\/wp-json\/wp\/v2\/tags?post=196"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}