{"id":11345,"date":"2016-11-18T17:25:57","date_gmt":"2016-11-18T09:25:57","guid":{"rendered":"http:\/\/buzzorange.com\/citiorange\/2016\/11\/18\/taida-thesis-scandal\/"},"modified":"2016-11-18T17:25:57","modified_gmt":"2016-11-18T09:25:57","slug":"taida-thesis-scandal","status":"publish","type":"post","link":"https:\/\/buzzorange.com\/citiorange\/2016\/11\/18\/taida-thesis-scandal\/","title":{"rendered":"\u3010\u53f0\u5927\u6821\u9577\u639b\u540d4\u7bc7\u9020\u5047\u8ad6\u6587\u3011\u53f0\u592711\u7bc7\u8ad6\u6587\u88ab\u5916\u570b\u4eba\u767c\u73fe\u9020\u5047\uff0c\u6839\u672c\u662f\u6700\u4e1f\u81c9\u5b78\u5e9c"},"content":{"rendered":"

\u3010\u6211\u5011\u70ba\u4ec0\u9ebc\u6311\u9078\u9019\u7bc7\u6587\u7ae0\u3011\u570b\u5916\u540c\u884c\u8ad6\u6587\u5be9\u67e5\u7db2\u7ad9PubPeer<\/a>\u8e22\u7206\u53f0\u5927\u5b78\u8853\u8ad6\u6587\u4f5c\u5047\uff01\u88ab\u767c\u73fe\u4f5c\u5047\u768411\u7bc7\u53f0\u5927\u8ad6\u6587\u4e2d\uff0c\u9084\u67094\u7bc7\u662f\u53f0\u5927\u73fe\u4efb\u6821\u9577\u694a\u6cee\u6c60\u64d4\u4efb\u5171\u540c\u639b\u540d\u7684\u8ad6\u6587\u3002<\/span><\/p>\n

\u4e4b\u524d\u5c31\u6709\u9000\u4f11\u6559\u6388\u767c\u8868\u6587\u7ae0<\/a>\u6279\u8a55\u8ad6\u6587\u6b6a\u98a8\uff0c\u73fe\u5728\u53c8\u88ab\u7206\u51fa\u9023\u53f0\u5927\u7684\u8ad6\u6587\u4e5f\u9020\u5047\uff0c\u53f0\u7063\u7684\u5b78\u8853\u754c\u5230\u5e95\u600e\u9ebc\u4e86\uff1f\uff08\u8cac\u4efb\u7de8\u8f2f\uff1a\u9ec3\u7b71\u96ef\uff09<\/span><\/p><\/blockquote>\n

\"20161117161727618913\"

\u8ad6\u6587\u5be9\u67e5\u7db2\u7ad9PubPeer\u8e22\u7206\uff0c\u53f0\u5927\u751f\u7269\u5316\u5b78\u6240\u6559\u6388\u90ed\u660e\u826f\u6240\u5e36\u9818\u7684\u7814\u7a76\u5718\u968a\uff0c\u88ab\u6aa2\u8209\u591a\u905411\u7bc7\u8ad6\u6587\u6d89\u53ca\u9020\u5047\uff0c\u5176\u4e2d\u67094\u7bc7\u70ba\u53f0\u5927\u6821\u9577\u694a\u6cee\u6c60\u5171\u540c\u639b\u540d\uff0c\u5f71\u97ff\u5c64\u9762\u4e0d\u53ea\u5305\u62ec\u53f0\u5927\u8072\u8b7d\uff0c\u4ea6\u8b93\u53f0\u7063\u751f\u91ab\u754c\u5728\u570b\u969b\u8499\u7f9e\u3002\uff08\u5408\u6210\u756b\u9762\uff0f\u7ffb\u651d\u81ea\u53f0\u5927\uff09<\/p><\/div>\n

\u53f0\u5927\u751f\u7269\u5316\u5b78\u6240\u6559\u6388\u90ed\u660e\u826f<\/a>\u6240\u5e36\u9818\u7684\u7814\u7a76\u5718\u968a\uff0c\u65e5\u524d\u906d\u570b\u5916\u540c\u884c\u8ad6\u6587\u5be9\u67e5\u7db2\u7ad9PubPeer<\/a>\u8e22\u7206\uff0c\u67095\u7bc7\u8ad6\u6587\u5728\u4e0d\u540c\u5be6\u9a57\u6578\u64da\u4e0a\u4f7f\u7528\u540c\u4e00\u5f35\u7167\u7247\uff0c\u6d89\u53ca\u8ad6\u6587\u9020\u5047\uff0c\u9055\u53cd\u5b78\u8853\u502b\u7406\u3002<\/p>\n

\u64da\u6307\u51fa\uff0cPubPeer\u7db2\u7ad9\u4e0a\u5df2\u6380\u8d77\u300c\u8d77\u5e95\u300d\u53f0\u7063\u8ad6\u6587\u6f6e\uff0c\u8207\u90ed\u660e\u826f\u6709\u95dc\u7684\u7814\u7a76\u5718\u968a\uff0c\u88ab\u6aa2\u8209\u4e86\u591a\u905411\u7bc7\u8ad6\u6587\u6d89\u53ca\u9020\u5047\uff0c\u66f4\u56b4\u91cd\u7684\u662f\uff0c\u5176\u4e2d\u67094\u7bc7\u70ba\u53f0\u5927\u6821\u9577\u694a\u6cee\u6c60\u5171\u540c\u639b\u540d\uff0c\u7279\u5225\u662f\u57282006\u5e74\u570b\u885b\u9662\u764c\u7814\u6240\u526f\u7814\u7a76\u54e1\u8607\u632f\u826f<\/a>\u5728\u300aCancer Cell\u300b\u671f\u520a\u6240\u767c\u8868\u7684\u8ad6\u6587\uff0c\u694a\u6cee\u6c60<\/a>\u66f4\u662f\u4ee5\u7b2c\u4e8c\u4f5c\u8005\u5171\u540c\u639b\u540d\uff0c\u4f7f\u5f97\u6574\u500b\u8ad6\u6587\u9020\u5047\u7684\u767c\u5c55\uff0c\u4e0d\u53ea\u9020\u6210\u53f0\u5927\u8072\u8b7d\u53d7\u5f71\u97ff\uff0c\u9023\u53f0\u7063\u751f\u91ab\u754c\u90fd\u5728\u570b\u969b\u4e0a\u8499\u7f9e\uff0c\u8eab\u70ba\u53f0\u5927\u6821\u9577\u53ca\u53f0\u7063\u816b\u7624\u6b0a\u5a01\u7684\u694a\u6cee\u6c60\uff0c\u662f\u5426\u61c9\u8a72\u8fad\u8077\u4ee5\u8ca0\u8cac\uff0c\u6709\u5f85\u89c0\u5bdf\u3002<\/p>\n

\"_506\"

\u6839\u64da\u8ad6\u6587\u5be9\u67e5\u7db2\u7ad9PubPeer\uff0c\u570b\u885b\u9662\u764c\u7814\u6240\u526f\u7814\u7a76\u54e1\u8607\u632f\u826f2006\u5e74\u5728\u300aCancer Cell\u300b\u671f\u520a\u6240\u767c\u8868\u7684\u8ad6\u6587\uff0c\u694a\u6cee\u6c60\u4ee5\u7b2c\u4e8c\u4f5c\u8005\u5171\u540c\u639b\u540d\u3002\uff08\u7ffb\u651d\u81eaPubPeer\uff09<\/p><\/div>\n

\u901911\u7bc7\u88ab\u6aa2\u8209\u9020\u5047\u7684\u8ad6\u6587\uff0c\u5f9e2004\u5e74\u52302016\u5e74\u90fd\u6709\uff0c\u5176\u4e2d\u6700\u5927\u7684\u7279\u8272\u662f\uff0c\u8ad6\u6587\u7b2c\u4e00\u4f5c\u8005\u5e7e\u4e4e\u6e05\u4e00\u8272\u90fd\u662f\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u526f\u6821\u9577\u3001\u53f0\u5927\u751f\u5316\u79d1\u5b78\u7814\u7a76\u6240\u535a\u58eb\u90ed\u660e\u826f\u7684\u5b78\u751f\uff0c\u53ea\u67092\u7bc7\u662f2008\u5e74\u53f0\u5927\u91ab\u9662\u8033\u9f3b\u5589\u79d1\u91ab\u52d9\u7955\u66f8\u517c\u767c\u8a00\u4eba\u8b5a\u6176\u9f0e<\/a>\u548c\u53f0\u5927\u91ab\u9662\u526f\u9662\u9577\u6797\u660e\u71e6<\/a>\u7684\u8ad6\u6587\uff0c\u548c\u90ed\u660e\u826f\u6c92\u6709\u5e2b\u751f\u95dc\u4fc2\u3002<\/p>\n

\"11\u7bc7\u8ad6\u6587\u9020\u5047\u540d\u55ae_1\"<\/p>\n

\u4e0d\u904e\u5de7\u5408\u7684\u662f\uff0c\u90ed\u660e\u826f\u662f1989\u5e74\u53f0\u5927\u751f\u5316\u6240\u535a\u58eb\uff0c\u6307\u5c0e\u6559\u6388\u70ba\u6797\u4ec1\u6df7\uff0c\u800c\u8b5a\u6176\u9f0e\u5247\u662f2000\u5e74\u53f0\u5927\u6bd2\u7406\u5b78\u7814\u7a76\u6240\u535a\u58eb\uff0c\u6307\u5c0e\u6559\u6388\u856d\u6c34\u9280\u548c\u6797\u4ec1\u6df7\u662f\u592b\u59bb\u95dc\u4fc2\u3002<\/p>\n

\u5176\u4ed6\u8ad6\u6587\u7684\u7b2c\u4e00\u4f5c\u8005\u51719\u7bc7\uff0c\u53f0\u5927\u535a\u58eb\u5f8c\u751f\u67e5\u8a69\u5a77\uff082016\u5e74\u30012010\u5e74\uff09\u5171\u5169\u7bc7\uff0c\u53f0\u5927\u53e3\u8154\u751f\u7269\u79d1\u5b78\u7814\u7a76\u6240\u6559\u6388\u5f35\u6b63\u742a\uff082013\u5e74\u30012016\u5e74\u30012004\u5e74\uff09\u5171\u4e09\u7bc7\uff0c\u8607\u632f\u826f\uff082007\u5e74\u30012006\u5e74\u30012006\u5e74\uff09\u5171\u4e09\u7bc7\uff0c\u53f0\u5927\u5916\u79d1\u91ab\u5e2b\u526f\u6559\u6388\u6797\u672c\u4ec1\uff082007\u5e74\uff09\u5171\u4e00\u7bc7\uff0c\u90199\u7bc7\u7684\u7b2c\u4e00\u4f5c\u8005\uff0c\u90ed\u660e\u826f\u90fd\u662f\u4ed6\u5011\u7684\u535a\u58eb\u6307\u5c0e\u6559\u6388\uff0c\u6574\u500b\u8ad6\u6587\u9020\u5047\u4f3c\u4e4e\u662f\u6709\u7d50\u69cb\u6027\u7684\u8108\u7d61\u53ef\u5faa\u3002<\/p>\n

\"_505\"<\/p>\n

\u81f3\u65bc\uff0c\u53f0\u5927\u6821\u9577\u694a\u6cee\u6c60\u5171\u540c\u639b\u540d\u7684\u9020\u5047\u8ad6\u6587\uff0c\u5247\u662f\u57282006\u5e74\u8607\u632f\u826f\u57f7\u7b46\u8ad6\u6587\uff0c\u694a\u6cee\u6c60\u70ba\u7b2c\u4e8c\u4f5c\u8005\uff1b\u53ca2006\u5e74\u53e6\u5916\u4e00\u7bc7\u8607\u632f\u826f\u7684\u8ad6\u6587\u3001\u5f35\u6b63\u742a2006\u5e74\u53ca2004\u5e74\u7684\u8ad6\u6587\u4e2d\u64d4\u4efb\u5171\u540c\u4f5c\u8005\uff0c\u90194\u7bc7\u4e2d\u67092\u7bc7\u5c31\u662f\u694a\u6cee\u6c60\u5c08\u7cbe\u7684\u764c\u75c7\u7cbe\u6e96\u6cbb\u7642\u7684\u57fa\u790e\u8ad6\u6587\u3002<\/p>\n

\"_508\"

PubPeer\u7db2\u7ad9\u4e0a\u6380\u8d77\u300c\u8d77\u5e95\u300d\u53f0\u7063\u8ad6\u6587\u6f6e\uff0c\u67094\u7bc7\u70ba\u53f0\u5927\u6821\u9577\u694a\u6cee\u6c60\u5171\u540c\u639b\u540d\uff0c\u5176\u4e2d2\u7bc7\u5c31\u662f\u694a\u6cee\u6c60\u5c08\u7cbe\u7684\u764c\u75c7\u7cbe\u6e96\u6cbb\u7642\u7684\u57fa\u790e\u8ad6\u6587\u3002\uff08\u7ffb\u651d\u81eaPubPeer\uff09<\/p><\/div>\n

\u53f0\u5927\u4e3b\u79d8\u6797\u9054\u5fb7\u8868\u793a\uff0cPubPeer\u70ba\u5b78\u8853\u754c\u540c\u884c\u533f\u540d\u6aa2\u8209\u7db2\u7ad9\uff0c\u8ab0\u90fd\u53ef\u4ee5\u4e0a\u53bb\u6aa2\u8209\uff0c\u800c\u4e14\u662f\u533f\u540d\u6aa2\u8209\uff0c\u78ba\u5be6\u6709\u4e9b\u722d\u8b70\u3002\u4e0d\u904e\u53f0\u5927\u6210\u7acb\u7279\u5225\u59d4\u54e1\u6703\u8abf\u67e5\u6b64\u4e8b\uff0c\u5c07\u9080\u8acb\u5916\u90e8\u5c08\u5bb6\u5b78\u8005\u5171\u540c\u6aa2\u8996\uff0c\u53ea\u8981\u6709\u4eba\u5728\u7db2\u7ad9\u4e0a\u63d0\u51fa\u5408\u7406\u8cea\u7591\uff0c\u8abf\u67e5\u5c0f\u7d44\u5c31\u6703\u9032\u884c\u516c\u6b63\u5be9\u67e5\u3002<\/p>\n

\u53f0\u5927\u5b98\u7db2\u65e5\u524d\u5728\u300c\u53f0\u5927\u6821\u8a0a\u300d\u4ee5\u7db2\u8def\u982d\u689d\u76db\u8b9a\u90ed\u660e\u826f\u6210\u529f\u89e3\u958b\u7d44\u86cb\u767d\u7532\u57fa\u8f49\u79fb\u9176\uff08G9a\uff09\u5982\u4f55\u8abf\u63a7\u5927\u8178\u764c\u5e79\u7d30\u80de\u5206\u5316\u80fd\u529b\u7684\u5206\u5b50\u6a5f\u5236\uff0c\u7d50\u679c\u906dPubPeer\u8e22\u7206\u67095\u7bc7\u8ad6\u6587\uff0c\u5be6\u9a57\u5716\u7247\u91cd\u8986\u4f7f\u7528\uff0c\u9055\u53cd\u5b78\u8853\u502b\u7406\uff0c\u4f5c\u8005\u5df2\u91dd\u5c0d\u5169\u7bc7\u4e3b\u52d5\u8072\u660e\u64a4\u7a3f\u3002<\/p>\n

\"74e83e46f89e360221b21aa706ed64b7\"

\u53f0\u5927\u5b98\u7db2\u65e5\u524d\u5728\u300c\u53f0\u5927\u6821\u8a0a\u300d\u4ee5\u7db2\u8def\u982d\u689d\u76db\u8b9a\u90ed\u660e\u826f\u7684\u764c\u75c7\u7814\u7a76\u65b0\u767c\u73fe\u3002\uff08\u7ffb\u651d\u756b\u9762\uff09<\/p><\/div>\n

\u672c\u5831\u63a5\u7372\u7206\u6599\u6307\u51fa\uff0cPubPeer\u4e0a\u958b\u59cb\u5927\u91cf\u6aa2\u8209\u53f0\u7063\u751f\u6280\u8ad6\u6587\uff0c\u90ed\u660e\u826f\u6240\u5e36\u9818\u5718\u968a\u7d04\u670911\u7bc7\u88ab\u540c\u884c\u6aa2\u8209\u6709\u9020\u5047\u5acc\u7591\uff0c\u5176\u4e2d\u67094\u7bc7\u694a\u6cee\u6c60\u639b\u5171\u540c\u4f5c\u8005\uff0c\u8b93\u751f\u5316\u5b78\u754c\u7c60\u7f69\u5728\u9020\u5047\u7591\u96f2\u7576\u4e2d\u3002<\/p>\n

\u5176\u4e2d\u88ab\u5217\u70ba\u53f0\u7063\u5341\u5927\u5973\u9752\u5e74\u3001\u53f0\u5927\u53e3\u8154\u751f\u7269\u6240\u6559\u6388\u5f35\u6b63\u742a\u57282006\u5e74\u767c\u8868\u7684\u8ad6\u6587\u300cEffect of connective tissue growth factor on hypoxia-inducible factor 1alpha degradation and tumor angiogenesis\u300d\uff0c\u7814\u7a76\u7d50\u7de0\u7d44\u7e54\u751f\u9577\u56e0\u5b50\uff0c\u4e5f\u88ab\u8e22\u7206\u5716\u7247\u9020\u5047\uff0c\u4e00\u5f35\u5716\u7247\u88ab\u91cd\u8986\u8cbc\u5728\u5169\u7a2e\u4e0d\u540c\u6a23\u672c\u4e4b\u4e2d\u3002<\/p>\n

\u8ad6\u6587\u5716\u7247\u96f7\u540c\u3000\u751f\u5316\u754c\u7814\u7a76\u54e1\uff1a\u5be6\u5728\u592a\u8a87\u5f35<\/strong><\/h2>\n

\u751f\u5316\u754c\u7814\u7a76\u54e1\u5411\u8a18\u8005\u5206\u6790\uff0c\u8a72\u8ad6\u6587\u7528\u5c0f\u8001\u9f20\u5be6\u9a57\u7d50\u7de0\u7d44\u7e54\u751f\u9577\u56e0\u5b50\uff0c\u80fd\u5426\u6291\u5236\u764c\u7d30\u80de\uff0c\u7b2c\u4e00\u7d44\u5716\u7247\u70ba\u5c0f\u8001\u9f20\u5b8c\u5168\u6c92\u6709\u88ab\u65bd\u6253\u85e5\u5291\u7684\u63a7\u5236\u7d44\uff0c\u7b2c\u4e8c\u7d44\u70ba\u52a0\u5165\u7d50\u7de0\u7d44\u7e54\u751f\u9577\u56e0\u5b50\uff0c\u7b2c\u4e09\u7d44\u7d50\u7de0\u7d44\u7e54\u751f\u9577\u56e0\u5b50\u52a0\u4e0a\u7f3a\u6c27\u8a98\u5c0e\u56e0\u5b50\uff0c\u7d50\u679c\u7b2c\u4e09\u7d44f\u5716\u7167\u7247\uff0c\u5c45\u7136\u8207d\u5716\u96f7\u540c\uff0c\u5be6\u5728\u592a\u8a87\u5f35\uff0c\u4e5f\u6703\u8aa4\u5c0e\u751f\u6280\u754c\u767c\u5c55\u3002<\/p>\n

\u6797\u9054\u5fb7\u8868\u793a\uff0c\u5716\u7247\u5982\u679c\u5b8c\u5168\u9577\u4e00\u6a23\uff0c\u78ba\u5be6\u6709\u4ee4\u4eba\u61f7\u7591\u4e4b\u8655\uff0c\u4e0d\u904e\u6bcf\u500b\u4eba\u5224\u65b7\u5716\u7247\u662f\u5426\u4e00\u6a23\u7684\u5b9a\u7fa9\u4e0d\u540c\uff0c\u9084\u5fc5\u9808\u4ea4\u7531\u5c08\u5bb6\u4f86\u5224\u65b7\u624d\u884c\uff0c\u9019\u90e8\u5206\u53f0\u5927\u4e5f\u6703\u8abf\u67e5\u6e05\u695a\u3002<\/p>\n

\"7_51\"

J. Natl. Cancer Inst., 98 (2006) \u671f\u520a\u4e2d\uff0cFig. 6a\u672c\u61c9\u9a57\u8b49CTGF\u8868\u9054\u548c\u816b\u7624\u751f\u9577\u548c\u9ad4\u5167\u8840\u7ba1\u751f\u6210\u7684\u95dc\u4fc2\u3002 \u5229\u7528\u55ae\u514b\u9686\u5c0f\u9f20\u6297\u4ebaCD31\u6297\u9ad4\u67d3\u8272\u6642\uff0c\u770b\u51faCTGF\u7684\u6548\u679c\u8207CTGF\u88abHIF-1a\u6291\u5236\u7684\u6548\u679c\u3002\u57fa\u65bc\u9019\u7a2e\u9810\u671f\uff0c\u8a72\u7814\u7a76\u5718\u968a\uff0c\u8a8d\u70ba\u5716e\u8207f\u61c9\u8a72\u985e\u4f3c\uff0c\u800c\u76f4\u63a5\u5c07\u7528\u540c\u4e00\u500b\u5207\u7247\u7684\u7167\u7247\u88fd\u6210\u5716d\u8207\u5716f\u3002\uff08\u7ffb\u651d\u81eaPubPeer\uff09<\/p><\/div>\n

\"8_64\"

Cancer Research (2004) \u8207Cancer Research (2006)\u671f\u520a\u4e2d\uff0c\u660e\u986f\u53ef\u4ee5\u770b\u5230Cancer Research (2004) Fig. 5B\u8207Cancer Research (2006) Fig. 1b\u662f\u900f\u904ephotoshop \u628a\u5f71\u50cf\u653e\u5927\u6539\u8b8a\u6df1\u6dfa\u5ea6\u518d\u79fb\u82b1\u63a5\u6728\u65b9\u5f0f\u507d\u9020\u6578\u64da\u3002\u672c\u61c9\u89c0\u5bdf\u80ba\u764c\u7d44\u7e54\u7684\u514d\u75ab\u7d44\u7e54\u5316\u5b78\u7d50\u7de0\u7d44\u7e54\u751f\u9577\u56e0\u5b50\uff08CTGF\uff09\u8868\u9054\u4e0b\u7684\u578b\u614b\u3002\u5c0d\u4f86\u81ea\u4eba\u539f\u767c\u6027\u80ba\u816b\u7624\uff08N = 24\uff09\u7684\u5207\u7247\u9032\u884c\u8655\u7406\u7528\u6297CTGF\u6297\u9ad4\u9032\u884c\u514d\u75ab\u7d44\u7e54\u5316\u5b78\u5206\u6790\uff0c\u4f3c\u4e4e\u662f\u500b\u8b0a\u8a00\uff0cN=0\u3002\uff08\u7ffb\u651d\u81eaPubPeer\uff09<\/p><\/div>\n

\"13_16\"

PubPeer\u8e22\u7206\uff0c\u8207\u90ed\u660e\u826f\u6709\u95dc\u7684\u7814\u7a76\u5718\u968a\uff0c\u88ab\u6aa2\u8209\u4e86\u591a\u905411\u7bc7\u8ad6\u6587\u3001\u5716\u7247\u6d89\u53ca\u9020\u5047\u3002\uff08\u7ffb\u651d\u81eaPubPeer\uff09<\/p><\/div>\n

\"14_13\"

Cancer Research (2006) \u671f\u520a\u4e2d\uff0cFig, 5c \u672c\u61c9\u89c0\u6e2c\u6291\u5236CNTN-1\u8868\u9054\u524a\u5f31\u4e86\u80ba\u817a\u764c\u7d30\u80de\u8f49\u79fb\u5230\u80ba\u7684\u80fd\u529b\u3002\u4f7f\u7528A549\u7d30\u80de\u8207CL 1-5\u7d30\u80de\uff0c\u5229\u7528siRNA-2\u6291\u5236CNTN-1\u8868\u9054\uff0c\u770b\u6709\u7121\u524a\u5f31\u80ba\u817a\u764c\u7d30\u80de\u8f49\u79fb\u5230\u80ba\u7684\u80fd\u529b\uff0c\u6b64\u8655\u70ba\u964d\u4f4eRhoA-GTP\u7684\u91cf\u8207RhoA-GTP\/Total RhoA\u6bd4\u4f8b\u3002\u70ba\u4e86\u660e\u78ba\u77e5\u9053\u5be6\u9a57\u86cb\u767d\u90fd\u662f\u5728\u76f8\u540c\u7684\u7e3d\u91cf\u4e0b\u6bd4\u8f03\uff0c\u6703\u4ee5b-actin \u7576\u4f5c\u63a7\u5236\u7d44\uff0c\u5176\u91cf\u61c9\u8a72\u662f\u4e00\u81f4\u7684\u3002\u6b64\u8655\u56e0\u70ba\u8a72\u7814\u7a76\u5718\u968a\uff0c\u8a8d\u70batotal RhoA\u61c9\u8a72\u5dee\u5225\u4e0d\u5927\uff0c\u800c\u76f4\u63a5\u5c07CL 1-5\/siRNA-2\u7684b-actin \u63a7\u5236\u7d44\u8907\u88fd\u8cbc\u4e0a\u6210A549\/control\u7684total RhoA\u5716\u3002\uff08\u7ffb\u651d\u81eaPubPeer\uff09<\/p><\/div>\n

\"15_13\"

Cancer Research (2006) \u671f\u520a\u4e2d\uff0cFig, 3a,b \u672c\u61c9\u89c0\u6e2cCNTN-1\u8207RhoA\u5171\u5b9a\u4f4d\u4e26\u4e14\u662fRhoA\u6d3b\u5316\u6240\u9700\u7684\u3002\u5716a\u662f\u70ba\u5206\u86cb\u767d\u65bc\u7d30\u80de\u819c\u4e0a\u8207\u7d30\u80de\u8cea\u4e2d\u7684\u5168\u86cb\u767d\u5be6\u9a57\u3002\u5716b\u662f\u5206\u6210\u65bc\u7d30\u80de\u819c\u4e0a\u8207\u7d30\u80de\u8cea\u4e2d\u7684\u5be6\u9a57\u3002\u6b64\u8655\u56e0\u70ba\u8a72\u7814\u7a76\u5718\u968a\uff0c\u8a8d\u70baCNTN-1\u8207RhoA\u61c9\u8655\u76f8\u540c\u4f4d\u7f6e\uff0c\u56e0\u6b64\u5716b A549\u7d30\u80de\u5728\u7d30\u80de\u819c\u4e0a\uff0c\u61c9\u5e7e\u7121\u86cb\u767d\uff0c\u6240\u4ee5\u4e0d\u8ad6\u6709\u7121\u6291\u5236CNTN-1\u7686\u5982\u6b64\uff0c\u800c\u76f4\u63a5\u5c07\u5716a CL 1-5\u7d30\u80de\u88abSiRNA-2\u6291\u5236CNTN-1\u7684\u6709\u7279\u5fb5\u75d5\u8de1\u7684RhoA-GTP\u8907\u88fd\u8cbc\u4e0a\u6210\u5716b A549\u7d30\u80de\u5728\u7d30\u80de\u819c\u4e0a\uff0cRac-1\u7684\u5716\u3002 \u9019\u4e9b\u897f\u65b9\u58a8\u9ede\u5716\uff08western blot\uff09\u7d93\u904ephotoshop \u5f71\u50cf\u8907\u88fd\u7d44\u5408\u79fb\u82b1\u63a5\u6728\u7684\u65b9\u5f0f\u507d\u9020\u6578\u64da\u3002\uff08\u7ffb\u651d\u81eaPubPeer\uff09<\/p><\/div>\n

\u5ef6\u4f38\u95b1\u8b80<\/p>\n

\u53f0\u7063\u6559\u6388\u7684\u6c89\u75db\u544a\u767d\uff1a\u5b78\u8853\u8ad6\u6587\u6dea\u70ba\u8a08\u7b97\u8eab\u50f9\u7684\u6a19\u6e96\uff0c\u6c92\u6709\u5f97\u5230\u8a8d\u8b49\u4f60\u5c31\u4ec0\u9ebc\u90fd\u4e0d\u662f<\/a>\u70ba\u4f55\u53f0\u5927\u6587\u7d44\u7562\u696d\u624d\u62ff22K\uff1f\u4e00\u4f4d\u53f0\u5927\u4eba\u8aaa\u51fa\u771f\u76f8\uff1a\u81ea\u5df1\u4e0d\u9858\u63d0\u65e9\u9762\u5c0d\u73fe\u5be6\uff0c\u602a\u8ab0\uff1f\u7576\u4e00\u4f4d\u8001\u5e2b\u70ba\u4e86\u5347\u5b78\u7387\u8aaa\u51fa\u300c\u8981\u8df3\u4e5f\u4e0d\u8df3\u6b7b\u300d\u2014\u2014\u53f0\u7063\u6559\u80b2\u9084\u8981\u88fd\u9020\u5e7e\u500b\u8df3\u6a13\u5efa\u4e2d\u5c11\u5e74\uff1f<\/a><\/p>\n

\uff08\u672c\u6587\u7d93\u5408\u4f5c\u5925\u4f34\u4e0a\u5831\u6388\u6b0a\u8f49\u8f09\uff0c\u4e26\u540c\u610f TechOrange \u7de8\u5beb\u5c0e\u8b80\u8207\u4fee\u8a02\u6a19\u984c\uff0c\u539f\u6587\u6a19\u984c\u70ba\u3008\u3010\u7368\u5bb6\u3011PubPeer\u8e22\u7206\uff01\u53f0\u5927\u9020\u5047\u8ad6\u658711\u7bc7\u3000\u694a\u6cee\u6c60\u5171\u540c\u639b\u540d4\u7bc7<\/a>\u3009\u3002\uff09<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u6211\u5011\u70ba\u4ec0\u9ebc\u6311\u9078\u9019\u7bc7\u6587\u7ae0\u3011\u570b\u5916\u540c\u884c\u8ad6\u6587\u5be9\u67e5\u7db2\u7ad9PubPeer\u8e22\u7206\u53f0\u5927\u5b78\u8853\u8ad6\u6587\u4f5c\u5047\uff01\u88ab\u767c\u73fe\u4f5c\u5047\u768411\u7bc7\u53f0\u5927\u8ad6\u6587\u4e2d\uff0c\u9084\u67094\u7bc7\u662f\u53f0\u5927\u73fe\u4efb\u6821\u9577\u694a\u6cee\u6c60\u64d4\u4efb\u5171\u540c\u639b\u540d\u7684\u8ad6\u6587\u3002 \u4e4b\u524d\u5c31\u6709\u9000\u4f11\u6559\u6388\u767c\u8868\u6587\u7ae0\u6279\u8a55\u8ad6\u6587\u6b6a\u98a8\uff0c[…]<\/p>\n","protected":false},"author":3,"featured_media":30442,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[1373,2660,28067,987,26222,670,2129,27812],"_links":{"self":[{"href":"https:\/\/buzzorange.com\/citiorange\/wp-json\/wp\/v2\/posts\/11345"}],"collection":[{"href":"https:\/\/buzzorange.com\/citiorange\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/buzzorange.com\/citiorange\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/buzzorange.com\/citiorange\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/buzzorange.com\/citiorange\/wp-json\/wp\/v2\/comments?post=11345"}],"version-history":[{"count":0,"href":"https:\/\/buzzorange.com\/citiorange\/wp-json\/wp\/v2\/posts\/11345\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/buzzorange.com\/citiorange\/wp-json\/wp\/v2\/media\/30442"}],"wp:attachment":[{"href":"https:\/\/buzzorange.com\/citiorange\/wp-json\/wp\/v2\/media?parent=11345"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/buzzorange.com\/citiorange\/wp-json\/wp\/v2\/categories?post=11345"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/buzzorange.com\/citiorange\/wp-json\/wp\/v2\/tags?post=11345"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}